Preparation of pH-sensitive porous polylactic acid-based medical dressing with self-pumping function

Zijian Zhang , Jianyong Li , Yi Wang , Xiaojie Wang , Liming Wang , Yinghua Qiu , Fangyi Li , Jianfeng Li , Maocheng Ji , Jia Man

School of Mechanical Engineering, Shandong University

Journal：《INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES》

Abstract：

Excessive exudation from the wound site and the difficulty of determining the state of wound healing can make medical management more difficult and, in extreme cases, lead to wound deterioration. In this study, we fabricated a pH-sensitive colorimetric chronic wound dressing with self-pumping function using electrostatic spinning technology. It consisted of three layers: a polylactic acid-curcumin (PCPLLA) hydrophobic layer, a hydrolyzed polyacrylonitrile (HPAN) transfer layer, and a polyacrylonitrile-purple kale anthocyanin (PAN-PCA) hydrophilic layer. The results showed that the preparation of porous PLLA fiber membrane loaded with 0.2 % Cur was achieved by adjusting the spinning-related parameters, which could ensure that the composite dressing had sufficient anti-inflammatory, antibacterial and antioxidant properties. The HPAN membrane treated with alkali for 30 min had significantly enhanced liquid wetting ability, and the unidirectional transport of liquid could be achieved by simple combination with the 20 um PCPLLA fiber membrane. In addition, the 4 % loaded PCA showed more obvious color difference than the colorimetric membrane. In vivo and ex vivo experiments have demonstrated the potential of multifunctional dressings for the treatment of chronic wounds.

Keywords: Self-pumping；Porous fiber；pH-sensitive

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