Physical, antibacterial, blood coagulation, and healing promotion evaluations of chitosan derivative-based composite films

Maocheng Ji , Fangyi Li , Jianyong Li , Jianfeng Li , Xiaojie Wang , Chuanwei Zhang , Sixian Peng , Jia Man

School of Mechanical Engineering, Shandong University

Journal：《INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES》

Abstract：

Chitosan is a potentially suitable material for wound dressing, but is undesirably water-insoluble. Although chitosan can be modified to produce water-soluble derivatives, the best chitosan derivative for wound dressings remains unclear. The present study introduced three water-soluble chitosan derivatives, namely, carboxymethyl chitosan, quaternized chitosan (QCS), and carboxymethyl quaternized chitosan, and explored the physical properties, biochemical properties, and wound care effectiveness of films of these derivatives. The QCS-based film exhibited higher absorption ability, mechanical properties, water-vapor permeability, electroconductivity, and antioxidant capacity than the other films. Most importantly, the cationic quaternary ammonium groups facilitated the antibacterial activity (>95 %) and blood coagulant capacity of the QCS-based film. As this film also promoted wound healing, it presented as an ideal candidate for wound dressings.

Keywords: Water solubility；Chitosan derivative；Wound care

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